3-(4-Chlorobenzoyl)-4-(4-chlorophenyl)-1-phenethylpiperidin-4-ol
نویسندگان
چکیده
In the title compound, C(26)H(25)Cl(2)NO(2), the piperidine ring adopts a chair conformation with a cis configuration of the carbonyl and hy-droxy substituents. The dihedral angle between the aromatic rings of the chloro-benzene groups is 24.3 (2)°. The phenyl ring forms dihedral angles of 59.4 (3) and 44.1 (3)° with the benzene rings. In the crystal, mol-ecules are linked by inter-molecular O-H⋯N and C-H⋯O hydrogen bonds and C-H⋯π inter-actions into layers parallel to the bc plane.
منابع مشابه
1-Methyl-3-trifluoromethyl-5-[(3-chlorophenyl)sulfanyl]-1H-pyrazole-4-carbaldehyde O-(4-chlorobenzoyl)oxime
In the title compound, C(19)H(12)Cl(2)F(3)N(3)O(2)S, the 3-chloro-phenyl and 4-chloro-phenyl rings form dihedral angles 89.5 (2) and 11.4 (2)°, respectively, with the pyrazole ring. In the crystal, mol-ecules related by translation along the a axis are linked into chains via C-H⋯N hydrogen bonds.
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The title compound, C(34)H(25)Cl(3)O(3)S(2)·0.5CH(3)OH, was synthesized by the reaction of thio-phene-2-carbaldehyde with acetophenone and NaOH under solvent-free conditions, using tetra-butylammonium bromide as a phase-transfer catalyst. The central six-membered ring adopts a chair conformation with the bulky thio-phene, 4-chloro-phenyl and 4-chloro-benzoyl substituents in equatorial positions...
متن کامل3-(4-Chlorobenzoyl)-6-(4-chlorophenyl)-2,4-dimethylbenzonitrile
In the title compound, C(22)H(15)Cl(2)NO, the terminal chloro-benzene rings are oriented at 44.51 (15) and 86.06 (17)° with respect to the central polysubstituted benzene ring, and make a dihedral angle of 49.48 (17)°with each other. In the crystal, mol-ecules are linked by weak C-H⋯O and C-H⋯N inter-actions.
متن کامل3′-(4-Chlorobenzoyl)-4′-(4-chlorophenyl)-1′-methylspiro[indoline-3,2′-pyrrolidin]-2-one
In the title compound, C(25)H(20)Cl(2)N(2)O(2), the pyrrolidine ring adopts an envelope conformation and the best plane through the five ring atoms makes a dihedral angle of 87.03 (8)° with the indoline ring. Mol-ecules are connected by pairs of N-H⋯O hydrogen bonds into centrosymmetric dimers with an R(2) (2)(8) graph-set ring motif. C-H⋯O hydrogen bonds stabilize the crystal structure.
متن کامل(1R*,2R*)-1-(4-Chlorophenyl)-4-dimethylamino-1-(3-methoxy-2-naphthyl)-2-(1-naphthyl)butan-2-ol
In the title compound, C(33)H(32)ClNO(2), the benzene ring is oriented at dihedral angles of 6.23 (5) and 66.44 (5)° with respect to the two naphthalene ring systems. An intra-molecular O-H⋯N hydrogen bond between the hydr-oxy H atom and the amine N atom generates an S(6) ring.
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